The use of molecular markers for cervical screening of women living with HIV in South Africa.

ABSTRACT:

Objective

To determine the performance of molecular screening strategies for detection of cervical intraepithelial neoplasia grade 3 or worse (CIN3+) in comparison with cytology screening in women living with HIV.

Design

Post-hoc analysis using data from a South African study cohort.

Methods

Cytology and human papillomavirus (HPV)-based strategies were evaluated, including single test and FAM19A4/miR124-2 methylation triage strategies. Participants underwent cytology screening and a colposcopy-directed biopsy. Valid results on cytology, HPV status, 16/18 genotyping and histology were available for 318 women. Detection of HPV and FAM19A4/miR124-2 hypermethylation was performed on DNA from cervical scrapes. Histological diagnosis of CIN3+ was used as outcome.

Results

SUBMITTER: Kremer WW 

PROVIDER: S-EPMC6791588 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature