TRPC channels are not required for graded persistent activity in entorhinal cortex neurons.

ABSTRACT: Adaptive behavior requires the transient storage of information beyond the physical presence of external stimuli. This short-lasting form of memory involves sustained ("persistent") neuronal firing which may be generated by cell-autonomous biophysical properties of neurons or/and neural circuit dynamics. A number of studies from brain slices reports intrinsically generated persistent firing in cortical excitatory neurons following suprathreshold depolarization by intracellular current injection. In layer V (LV) neurons of the medial entorhinal cortex (mEC) persistent firing depends on the activation of cholinergic muscarinic receptors and is mediated by a calcium-activated nonselective cation current (I_CAN ). The molecular identity of this conductance remains, however, unknown.

SUBMITTER: Egorov AV 

PROVIDER: S-EPMC6791731 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature