Phosphorylated Hexa-Acyl Disaccharides Augment Host Resistance Against Common Nosocomial Pathogens.

ABSTRACT:

Objectives

To determine whether synthetic phosphorylated hexa-acyl disaccharides provide antimicrobial protection in clinically relevant models of bacterial infection.

Design

Laboratory study.

Setting

University laboratory.

Subjects

BALB/c, C57BL/10J, and C57BL/10ScNJ mice.

Interventions

Mice were treated with lactated Ringer's (vehicle) solution, monophosphoryl lipid A, or phosphorylated hexa-acyl disaccharides at 48 and 24 hours prior to intraperitoneal Pseudomonas aeruginosa or IV Staphylococcus aureus infection. Leukocyte recruitment, cytokine production, and bacterial clearance were measured 6 hours after P. aeruginosa infection. In the systemic S. aureus infection model, one group of mice was monitored for 14-day survival and another for S. aureus

SUBMITTER: Hernandez A 

PROVIDER: S-EPMC6791756 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature