Association Between Triglyceride Lowering and Reduction of Cardiovascular Risk Across Multiple Lipid-Lowering Therapeutic Classes: A Systematic Review and Meta-Regression Analysis of Randomized Controlled Trials.

ABSTRACT:

Background

Randomized trials of therapies that primarily lowered triglycerides have not consistently shown reductions in cardiovascular events.

Methods

We performed a systematic review and trial-level meta-regression analysis of 3 classes of lipid-lowering therapies that reduce triglycerides to a greater extent than they do low-density lipoprotein cholesterol (LDL-C): fibrates, niacin, and marine-derived omega-3 fatty acids. Key inclusion criteria were a randomized controlled trial that reported major vascular events. We also incorporated data from a previous meta-regression of 25 statin trials. The main outcome measure was the risk ratio (RR) for major vascular events associated with absolute reductions in lipid parameters.

Results

A total of 197 270 participants fro

SUBMITTER: Marston NA 

PROVIDER: S-EPMC6791781 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature