High Throughput Experimentation Using DESI-MS to Guide Continuous-Flow Synthesis.

ABSTRACT: We demonstrate the use of accelerated reactions with desorption electrospray ionization mass spectrometry (DESI-MS) as a tool for predicting the outcome of microfluidic reactions. DESI-MS was employed as a high throughput experimentation tool to provide qualitative predictions of reaction outcomes, so that vast regions of chemical reactivity space may be more rapidly explored and areas of optimal efficiency identified. This work is part of a larger effort to accelerate reaction optimization to enable the rapid development of continuous-flow syntheses of small molecules in high yield. In order to build confidence in this approach, however, it is necessary to establish a robust predictive connection between reactions performed under analogous DESI-MS, batch, and microfluidic reaction conditi

SUBMITTER: Loren BP 

PROVIDER: S-EPMC6791872 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature