SIRPα expression delineates subsets of intratumoral monocyte/macrophages with different functional and prognostic impact in follicular lymphoma.

ABSTRACT: Signal regulatory protein-α (SIRPα) is a key member of the "do-not-eat-me" signaling pathway, but its biological role and clinical relevance in B-cell NHL is relatively unknown. Using biopsy specimens from follicular lymphoma (FL), we identified three subsets (CD14⁺SIRPα^hi, CD14^-SIRPα^low, and CD14^-SIRPα^neg) of monocyte/macrophages (Mo/MΦ) based on CD14 and SIRPα expression. CD14⁺SIRPα^hi cells expressed common Mo/MΦ markers; exhibited characteristic differentiation, migration, and phagocytosis; and suppressed T-cell function. CD14^-SIRPα^low cells expressed fewer typical Mo/MΦ markers; migrated less and phagocytosed tumor cells less efficiently; and stimulated rather than suppressed T

SUBMITTER: Chen YP 

PROVIDER: S-EPMC6791879 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature