Targeted Genomic Profiling of Acral Melanoma.

ABSTRACT:

Background

Acral melanoma is a rare type of melanoma that affects world populations irrespective of skin color and has worse survival than other cutaneous melanomas. It has relatively few single nucleotide mutations without the UV signature of cutaneous melanomas, but instead has a genetic landscape characterized by structural rearrangements and amplifications. BRAF mutations are less common than in other cutaneous melanomas, and knowledge about alternative therapeutic targets is incomplete.

Methods

To identify alternative therapeutic targets, we performed targeted deep-sequencing on 122 acral melanomas. We confirmed the loss of the tumor suppressors p16 and NF1 by immunohistochemistry in select cases.

Results

In addition to BRAF (21.3%), NRAS (27.9%), and KIT (11.5%)

SUBMITTER: Yeh I 

PROVIDER: S-EPMC6792090 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature