Immunosuppressive effect of hispidulin in allergic contact dermatitis.

ABSTRACT:

Background

Long-term use of most immunosuppressants to treat allergic contact dermatitis (ACD) generates unavoidable severe side effects, warranting discovery or development of new immunosuppressants with good efficacy and low toxicity is urgently needed to treat this condition. Hispidulin, a flavonoid compound that can be delivered topically due to its favorable skin penetrability properties, has recently been reported to possess anti-inflammatory and immunosuppressive properties. However, no studies have investigated the effect of hispidulin on Th1 cell activities in an ACD setting.

Methods

A contact hypersensitivity (CHS) mouse model was designed to simulate human ACD. The immunosuppressive effect of hispidulin was investigated via ear thickness, histologic changes (i.e.,

SUBMITTER: Thitilertdecha P 

PROVIDER: S-EPMC6792202 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature