Candidate single nucleotide polymorphisms of irritable bowel syndrome: a systemic review and meta-analysis.

ABSTRACT:

Background

Genetic factors increase the risk of irritable bowel syndrome (IBS). Analysis of single nucleotide polymorphisms (SNPs) has been used in IBS patients, but the findings are inconsistent. The goal of this review was to synthesize all the published SNPs studies of IBS through meta-analysis to objectively evaluate the relevance of SNPs to IBS risks.

Methods

IBS - related polymorphisms studies from 2000 to 2018 were searched. Pooled odds ratios with a 95% confidence interval for each SNP were evaluated through five genetic models. Ethnicity, ROME criteria and IBS subtypes were defined for subgroup analyze.

Results

Ten relevant genes were evaluated. SNPs rs4263839 and rs6478108 of TNFSF15 associated with an increased risk of IBS; IL6 rs1800795 increased the risk

SUBMITTER: Zhu S 

PROVIDER: S-EPMC6792237 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature