New potentiometric sensors for methylphenidate detection based on host-guest interaction.

ABSTRACT: The study aims to develop simple, sensitive, and selective methods for detecting methylphenidate in its bulk, dosage form and human urine. Sensing materials include β-cyclodextrin (β-CD), γ-cyclodextrin (γ-CD), and 4-tertbutylcalix[8]arene as ionophores or electroactive materials have been used for construction of sensors 1, 2, and 3, respectively; Potassium tetrakis (4-chlorophenyl)borate (KTpClPB) as an ion additive was used and dioctyl phthalate as a plasticizer. The sensors displayed a fast, stable response over a wide concentration range of methylphenidate (8 × 10-6 M to 1 × 10-3 M) with 10-6 M detection limit over the pH range of 4-8. The developed sensors displayed a Near-Nernstian cationic response for methylphenidate at 59.5, 51.37, and 56.5 mV/decade for sensors β-CD, γ-CD, or 4-

SUBMITTER: AlRabiah H 

PROVIDER: S-EPMC6792245 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature