Augmentation of peripheral lymphocyte-derived cholinergic activity in patients with acute ischemic stroke.

ABSTRACT:

Background

Brain ischemia activates the parasympathetic cholinergic pathway in animal models of human disease. However, it remains unknown whether activation of the cholinergic pathway impacts immune defenses and disease outcomes in patients with ischemic stroke. This study investigated a possible association between peripheral cholinergic activity, post-stroke infection, and mortality.

Methods

In this study, we enrolled 458 patients with acute ischemic stroke (< 24 h after onset), 320 patients with ischemic stroke on day 10, and 216 healthy subjects. Peripheral cholinergic activity, reflected by intracellular acetylcholine (ACh) content in human peripheral blood mononuclear cells (PBMCs), was determined by ultra-performance liquid chromatography-tandem mass spectrometry (UP

SUBMITTER: Yuan M 

PROVIDER: S-EPMC6792255 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature