Global impact of somatic structural variation on the DNA methylome of human cancers.

ABSTRACT: BACKGROUND:Genomic rearrangements exert a heavy influence on the molecular landscape of cancer. New analytical approaches integrating somatic structural variants (SSVs) with altered gene features represent a framework by which we can assign global significance to a core set of genes, analogous to established methods that identify genes non-randomly targeted by somatic mutation or copy number alteration. While recent studies have defined broad patterns of association involving gene transcription and nearby SSV breakpoints, global alterations in DNA methylation in the context of SSVs remain largely unexplored. RESULTS:By data integration of whole genome sequencing, RNA sequencing, and DNA methylation arrays from more than 1400 human cancers, we identify hundreds of genes and associated CpG i

SUBMITTER: Zhang Y 

PROVIDER: S-EPMC6792267 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature