High Throughput and Computational Repurposing for Neglected Diseases.

ABSTRACT:

Purpose

Neglected tropical diseases (NTDs) represent are a heterogeneous group of communicable diseases that are found within the poorest populations of the world. There are 23 NTDs that have been prioritized by the World Health Organization, which are endemic in 149 countries and affect more than 1.4 billion people, costing these developing economies billions of dollars annually. The NTDs result from four different causative pathogens: protozoa, bacteria, helminth and virus. The majority of the diseases lack effective treatments. Therefore, new therapeutics for NTDs are desperately needed.

Methods

We describe various high throughput screening and computational approaches that have been performed in recent years. We have collated the molecules identified in these studies and

SUBMITTER: Hernandez HW 

PROVIDER: S-EPMC6792295 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature