Oral Systemic Bioavailability of Bisphenol A and Bisphenol S in Pigs.

ABSTRACT:

Background

Given its hormonal activity, bisphenol S (BPS) as a substitute for bisphenol A (BPA) could actually increase the risk of endocrine disruption if its toxicokinetic (TK) properties, namely its oral availability and systemic persistency, were higher than those of BPA.

Objectives

The TK behavior of BPA and BPS was investigated by administering the two compounds by intravenous and oral routes in piglet, a known valid model for investigating oral TK.

Methods

Experiments were conducted in piglets to evaluate the kinetics of BPA, BPS, and their glucuronoconjugated metabolites in plasma and urine after intravenous administration of BPA, BPS, and BPS glucuronide (BPSG) and gavage administration of BPA and BPS. A population semiphysiologically based TK model describin

SUBMITTER: Gayrard V 

PROVIDER: S-EPMC6792350 | biostudies-literature | 2019 Jul

REPOSITORIES: biostudies-literature