Prenatal Exposure to Phthalates and Newborn Telomere Length: A Birth Cohort Study in Wuhan, China.

ABSTRACT:

Background

Telomere length (TL) is a marker of biological aging and is inversely related to aging-related diseases. The setting of TL at birth may have important implications for lifelong telomere dynamics; however, its determinants remain poorly understood.

Objectives

The purpose of our study was to explore the relationships between prenatal exposure to phthalates and umbilical cord blood TL.

Methods

A total of 762 mother–newborn pairs were recruited from a birth cohort study performed between November 2013 and March 2015 in Wuhan, China. Relative cord blood TL was measured using quantitative real-time polymerase chain reaction. Six phthalate metabolites were measured in urine samples acquired from pregnant women during the three trimesters. Multiple informant models

SUBMITTER: Song L 

PROVIDER: S-EPMC6792351 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature