Comparison of Bisphenol A and Bisphenol S Percutaneous Absorption and Biotransformation.

ABSTRACT:

Background

Bisphenol S (BPS) has been widely substituted for bisphenol A (BPA) on thermal papers, but little is known about its skin absorption.

Objectives

We compared the percutaneous absorption and biotransformation of BPS and BPA in vitro and in a controlled human trial.

Methods

Absorption and biotransformation of BPS and BPA were monitored across reconstructed human epidermis at two environmentally relevant doses over 25 h. In the human trial, five male participants handled thermal receipts containing BPS and washed their hands after 2 h. Urine (0-48 h) and serum (0-7.5h) were analyzed for target bisphenols, and one participant repeated the experiment with extended monitoring. BPS data were compared with published data for isotope-labeled BPA ([Formula: see text])

SUBMITTER: Liu J 

PROVIDER: S-EPMC6792388 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature