Vitamin D Status Modifies the Response to Indoor Particulate Matter in Obese Urban Children with Asthma.

ABSTRACT:

Background

Indoor fine particulate air pollution (PM_2.5) is linked to asthma morbidity; however, whether vitamin D status influences individual susceptibility to airborne exposures is unclear.

Objective

We aimed to determine if vitamin D modifies the effects of indoor PM_2.5 on asthma symptoms in urban children.

Methods

A total of 120 children aged 5 to 12 years with physician-diagnosed asthma were evaluated at baseline and every 3 months for 9 months. Indoor PM_2.5, serum 25-hydroxy vitamin D (25-OH D) levels, and asthma symptoms were simultaneously assessed at each time point. Adjusting for confounders, generalized estimating equations assessed the 3-way interaction effects of 25-OH D, obesity, and PM on asthma symptoms.

Results

SUBMITTER: Bose S 

PROVIDER: S-EPMC6792389 | biostudies-literature | 2019 Jul - Aug

REPOSITORIES: biostudies-literature