Local Delivery of Therapeutics to the Inner Ear: The State of the Science.

ABSTRACT: Background: Advances in the understanding of the genetic and molecular etiologies of inner ear disorders have enabled the identification of therapeutic targets and innovative delivery approaches to the inner ear. As this field grows, the need for knowledge about effective delivery of therapeutics to the inner ear has become a priority. This review maps all clinical and pre-clinical research published in English in the field to date, to guide both researchers and clinicians about local drug delivery methods in the context of novel therapeutics. Methods: A systematic search was conducted using customized strategies in Cochrane, pubmed and EMBASE databases from inception to 30/09/2018. Two researchers undertook study selection and data extraction independently. Results: O

SUBMITTER: Anderson CR 

PROVIDER: S-EPMC6794458 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature