Probiotic Yeasts Inhibit Virulence of Non-albicans Candida Species.

ABSTRACT: Systemic infections of Candida species pose a significant threat to public health. Toxicity associated with current therapies and emergence of resistant strains present major therapeutic challenges. Here, we report exploitation of the probiotic properties of two novel, food-derived yeasts, Saccharomyces cerevisiae (strain KTP) and Issatchenkia occidentalis (strain ApC), as an alternative approach to combat widespread opportunistic fungal infections. Both yeasts inhibit virulence traits such as adhesion, filamentation, and biofilm formation of several non-albicans Candida species, including Candida tropicalis, Candida krusei, Candida glabrata, and Candida parapsilosis as well as the recently identified multidrug-resistant species Ca

SUBMITTER: Kunyeit L 

PROVIDER: S-EPMC6794482 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature