Remasking of Candida albicans β-Glucan in Response to Environmental pH Is Regulated by Quorum Sensing.

ABSTRACT: Candida albicans is a commensal yeast of the human gut which is tolerated by the immune system but has the potential to become an opportunistic pathogen. One way in which C. albicans achieves this duality is through concealing or exposing cell wall pathogen-associated molecular patterns (PAMPs) in response to host-derived environment cues (pH, hypoxia, and lactate). This cell wall remodeling allows C. albicans to evade or hyperactivate the host's innate immune responses, leading to disease. Previously, we showed that adaptation of C. albicans to acidic environments, conditions encountered during colonization of the female reproductive tract, induces significant cell wall remodeling resulting in the exposure of two key fungal PAMPs (β-glucan and chitin). Here, we

SUBMITTER: Cottier F 

PROVIDER: S-EPMC6794483 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature