Environmental Electrophile-Mediated Toxicity in Mice Lacking Nrf2, CSE, or Both.

ABSTRACT:

Background

Transcription factor Nrf2 (nuclear factor-erythroid 2-related factor 2) plays a key role in detoxification of electrophiles via formation of glutathione (GSH) adducts and subsequent excretion into extracellular spaces. We found that reactive sulfur species (RSS), such as cysteine persulfides produced by cystathionine [Formula: see text] (CSE), capture environmental electrophiles through formation of sulfur adducts. However, contributions of Nrf2 and CSE to the blockage of environmental electrophile-mediated toxicity remain to be evaluated.

Objectives

The aim of this study was to clarify roles that CSE and Nrf2 play in the protection against various environmental electrophiles. We also wished to clarify the molecular basis of the developmental window of toxicity th

SUBMITTER: Akiyama M 

PROVIDER: S-EPMC6794492 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature