Association of Vitamin D receptor gene BsmI polymorphism with type 2 diabetes mellitus in Pakistani population.

ABSTRACT:

Background

Type 2 diabetes mellitus (T2DM) is a complex metabolic disorder with strong genetic components. The reported association of vitamin D receptor (VDR) gene polymorphisms varies among ethnic groups.

Objectives

The present study was conducted to determine association of vitamin D receptor gene BsmI (rs1544410 A>G) polymorphism with type 2 diabetes mellitus in Pakistani population.

Methods

Blood samples were collected from 150 T2DM patients and 100 non-diabetic engaged by convenient sampling method. After collection of demographic data, assessment of fasting glucose (FG), vitamin D, HbA1c, renal function tests, liver function tests and lipid profile was done. Candidate gene polymorphism was analyzed by DNA amplification with polymerase chain reaction and endonuclease digestion.

Results

Biochemical parameters were significantly different among case and control groups. Associations of BsmI genotype with T2DM, related complications and biochemical variables were not significant.

Conclusion

The current study did not provide evidence for the association of VDR gene BsmI polymorphism with T2DM in Pakistani population.

SUBMITTER: Fatma H 

PROVIDER: S-EPMC6794500 | biostudies-literature | 2019 Jun

REPOSITORIES: biostudies-literature