Injectable and Conductive Granular Hydrogels for 3D Printing and Electroactive Tissue Support.

ABSTRACT: Conductive hydrogels are attractive to mimic electrophysiological environments of biological tissues and toward therapeutic applications. Injectable and conductive hydrogels are of particular interest for applications in 3D printing or for direct injection into tissues; however, current approaches to add conductivity to hydrogels are insufficient, leading to poor gelation, brittle properties, or insufficient conductivity. Here, an approach is developed using the jamming of microgels to form injectable granular hydrogels, where i) hydrogel microparticles (i.e., microgels) are formed with water-in-oil emulsions on microfluidics, ii) microgels are modified via an in situ metal reduction process, and iii) the microgels are jammed into a solid, permitting easy extrusion from a syringe. Due to t

SUBMITTER: Shin M 

PROVIDER: S-EPMC6794627 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature