Protocol for the Study of Heart and Renal Protection-Extended Review: Additional 5-Year Follow-up of the Australian, New Zealand, and Malaysian SHARP Cohort.

ABSTRACT:

Background

There are limited studies on the effects of statins on outcomes in the moderate chronic kidney disease (CKD) population and their trajectory to end-stage kidney disease.

Objective

To examine the long-term effects of lipid-lowering therapy on all-cause mortality, cardiovascular morbidity, CKD progression, and socioeconomic well-being in Australian, New Zealand, and Malaysian SHARP (Study of Heart and Renal Protection) trial participants-a randomized controlled trial of a combination of simvastatin and ezetimibe, compared with placebo, for the reduction of cardiovascular events in moderate to severe CKD.

Design

Protocol for an extended prospective observational follow-up.

Setting

Australian, New Zealand, and Malaysian participating centers in patients

SUBMITTER: Sukkar L 

PROVIDER: S-EPMC6794650 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature