Inheritance of Neural Substrates for Motivation and Pleasure.

ABSTRACT: Despite advances in the understanding of the reward system and the role of dopamine in recent decades, the heritability of the underlying neural mechanisms is not known. In the present study, we examined the hemodynamic activation of the nucleus accumbens (NAcc), a key hub of the reward system, in 86 healthy monozygotic twins and 88 healthy dizygotic twins during a monetary-incentive-delay task. The participants also completed self-report measures of pleasure. Using voxelwise heritability mapping, we found that activation of the bilateral NAcc during the anticipation of monetary gains had significant heritability (h² = .20-.49). Moreover, significant shared genetic covariance was observed between pleasure and NAcc activation during the anticipation of monetary gain. These

SUBMITTER: Li Z 

PROVIDER: S-EPMC6794661 | biostudies-literature | 2019 Aug

REPOSITORIES: biostudies-literature