The gut virome in inflammatory bowel disease pathogenesis: From metagenomics to novel therapeutic approaches.

ABSTRACT: The association of intestinal dysbiosis with the pathogenesis of inflammatory bowel disease has been well established. Besides bacteria, microbiota comprises yeasts, archaea, protists and viruses, neglected actors in inflammatory bowel disease-associated microbiota. In the past, a great limitation in studying microbiota composition was the low sensitivity of sequencing technologies and that few computational approaches were sufficient to thoroughly analyse the whole microbiome. However, new cutting-edge technologies in nucleic acid sequencing, -omics analysis and the innovative statistics and bioinformatics pipelines made possible more sensitive and accurate metagenomics, ultimately identifying novel players in intestinal inflammation, including prokaryotic and eukaryotic viruses, that tog

SUBMITTER: Ungaro F 

PROVIDER: S-EPMC6794698 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature