Association of low-level blood lead with serum uric acid in U.S. adolescents: a cross-sectional study.

ABSTRACT: BACKGROUND:Uncertainty remains regarding the association between blood lead levels (BLL) and serum uric acid (SUA) with relatively low BLL exposure because of limited data in the adolescent population. We examined the association between BLL and SUA in U.S. adolescents. METHODS:In this cross-sectional study, 8303 adolescents aged 12-19 years from NHANES 1999-2006 were analyzed. BLL was Ln-transformed for analysis for the skewed distribution. Elevated SUA was defined as ≥5.5 mg/dL. Multivariate linear and multiple logistic regression analyses were performed to evaluate the association of BLL with SUA and elevated SUA. Moreover, a generalized additive model (GAM) and a fitted smoothing curve (penalized spline method) were conducted. RESULTS:The overall mean BLL was 1.3 μg/dL. Multivariate li

SUBMITTER: Hu G 

PROVIDER: S-EPMC6794798 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature