DIRECT: RNA contact predictions by integrating structural patterns.

ABSTRACT:

Background

It is widely believed that tertiary nucleotide-nucleotide interactions are essential in determining RNA structure and function. Currently, direct coupling analysis (DCA) infers nucleotide contacts in a sequence from its homologous sequence alignment across different species. DCA and similar approaches that use sequence information alone typically yield a low accuracy, especially when the available homologous sequences are limited. Therefore, new methods for RNA structural contact inference are desirable because even a single correctly predicted tertiary contact can potentially make the difference between a correct and incorrectly predicted structure. Here we present a new method DIRECT (Direct Information REweighted by Contact Templates) that incorporates a Restricted Bo

SUBMITTER: Jian Y 

PROVIDER: S-EPMC6794908 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature