Microbial Metabolic Capacity for Intestinal Folate Production and Modulation of Host Folate Receptors.

ABSTRACT: Microbial metabolites, including B complex vitamins contribute to diverse aspects of human health. Folate, or vitamin B₉, refers to a broad category of biomolecules that include pterin, para-aminobenzoic acid (pABA), and glutamate subunits. Folates are required for DNA synthesis and epigenetic regulation. In addition to dietary nutrients, the gut microbiota has been recognized as a source of B complex vitamins, including folate. This study evaluated the predicted folate synthesis capabilities in the genomes of human commensal microbes identified in the Human Microbiome Project and folate production by representative strains of six human intestinal bacterial phyla. Bacterial folate synthesis genes were ubiquitous across 512 gastrointestinal reference genomes with 13% of the genom

SUBMITTER: Engevik MA 

PROVIDER: S-EPMC6795088 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature