Use of acoustic emission to identify novel candidate biomarkers for knee osteoarthritis (OA).

ABSTRACT: Our objective was to determine the efficacy and feasibility of a new approach for identifying candidate biomarkers for knee osteoarthritis (OA), based on selecting promising candidates from a range of high-frequency acoustic emission (AE) measurements generated during weight-bearing knee movement. Candidate AE biomarkers identified by this approach could then be validated in larger studies for use in future clinical trials and stratified medicine applications for this common health condition. A population cohort of participants with knee pain and a Kellgren-Lawrence (KL) score between 1-4 were recruited from local NHS primary and secondary care sites. Focusing on participants' self-identified worse knee, and using our established movement protocol, sources of variation in AE measurement an

SUBMITTER: Schluter DK 

PROVIDER: S-EPMC6795455 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature