Enhancer-core-promoter specificity separates developmental and housekeeping gene regulation.

ABSTRACT: Gene transcription in animals involves the assembly of RNA polymerase II at core promoters and its cell-type-specific activation by enhancers that can be located more distally. However, how ubiquitous expression of housekeeping genes is achieved has been less clear. In particular, it is unknown whether ubiquitously active enhancers exist and how developmental and housekeeping gene regulation is separated. An attractive hypothesis is that different core promoters might exhibit an intrinsic specificity to certain enhancers. This is conceivable, as various core promoter sequence elements are differentially distributed between genes of different functions, including elements that are predominantly found at either developmentally regulated or at housekeeping genes. Here we show that thousands o

SUBMITTER: Zabidi MA 

PROVIDER: S-EPMC6795551 | biostudies-literature | 2015 Feb

REPOSITORIES: biostudies-literature