Structures of influenza A virus RNA polymerase offer insight into viral genome replication.

ABSTRACT: Influenza A viruses are responsible for seasonal epidemics, and pandemics can arise from the transmission of novel zoonotic influenza A viruses to humans^1,2. Influenza A viruses contain a segmented negative-sense RNA genome, which is transcribed and replicated by the viral-RNA-dependent RNA polymerase (FluPol_A) composed of PB1, PB2 and PA subunits^3-5. Although the high-resolution crystal structure of FluPol_A of bat influenza A virus has previously been reported⁶, there are no complete structures available for human and avian FluPol_A. Furthermore, the molecular mechanisms of genomic viral RNA (vRNA) replication-which proceeds through a complementary RNA (cRNA) replicative intermediate, and requires oligomerization of the poly

SUBMITTER: Fan H 

PROVIDER: S-EPMC6795553 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature