Variations in AXIN2 predict risk and prognosis of colorectal cancer.

ABSTRACT:

Objective

Colorectal cancer (CRC) and hypodontia are frequent and different diseases with common genes are involved in their etiology. The objective of this study was to identify the association between AXIN2 rs2240308 with hypodontia and CRC.

Patients and methods

This study consisted of 50 individuals with hypodontia, 50 individuals with CRC, and 155 healthy individuals from Colombia. SNP genotyping assays of rs2240308 were performed and family history of cancer in individuals with hypodontia was documented. In silico analysis was implemented to define the genomic profile of the AXIN2 gene associated with CRC. Multivariate analysis, chi square, odd ratio tests, and R software were used for statistical analysis.

Results

AXIN2 rs2240308 showed association with C

SUBMITTER: Otero L 

PROVIDER: S-EPMC6795800 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature