A Gas Phase Route to [¹⁸F]fluoroform with Limited Molar Activity Dilution.

ABSTRACT: Positron emission tomography (PET) is an important imaging modality for biomedical research and drug development. PET requires biochemically selective radiotracers to realize full potential. Fluorine-18 (t_1/2 = 109.8 min) is a major radionuclide for labeling such radiotracers but is only readily available in high activities from cyclotrons as [¹⁸F]fluoride ion. [¹⁸F]fluoroform has emerged for labeling tracers in trifluoromethyl groups. Prior methods of [¹⁸F]fluoroform synthesis used difluoro precursors in solution and led to high dilution with carrier and low molar activity (A_m). We explored a new approach for the synthesis of [¹⁸F]fluoroform based on the radiosynthesis of [¹⁸F]fluoromethane from [¹⁸F]f

SUBMITTER: Yang BY 

PROVIDER: S-EPMC6795885 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature