Combined cellular and soluble mediator analysis for improved diagnosis of vitreoretinal lymphoma.

ABSTRACT: PURPOSE:Primary vitreoretinal lymphoma [(P)VRL]) is a rare malignancy of the eye localized in the retina, vitreous or choroid. Here, we aim to determine the value of the combination of innovative diagnostic methods for accurate differentiation between (P)VRL and non-(P)VRL in patients with suspect uveitis or vitritis. METHODS:Multicolour flow cytometric immunophenotyping of cells in the vitreous samples was performed using the EuroFlow small sample tube. Additionally, cytokines/chemokines and growth factors were measured in the vitreous specimens using a multiplex immunoassay. Data were evaluated in predefined clinical subgroups using omniviz unsupervised Pearson's correlation visualization and unsupervised heatmap analysis. RESULTS:A total of 53 patients were prospectively included in the

SUBMITTER: de Hoog J 

PROVIDER: S-EPMC6796208 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature