Association of medication non-adherence with short-term allograft loss after the treatment of severe acute kidney transplant rejection.

ABSTRACT: BACKGROUND:Medication non-adherence is a risk factor for acute kidney transplant rejection. The association of non-adherence with short-term allograft loss in patients who develop acute rejection and are subsequently treated with maximal therapy is unknown. METHODS:We conducted a retrospective single center cohort study of adult patients who developed acute rejection from January 2003 to December 2017 and were treated with lymphocyte depletion. Clinicopathologic characteristics including adherence status were collected and descriptive statistics utilized to compare groups. The primary outcome was all-cause graft loss at 6 months after acute rejection treatment. A multivariable logistic regression quantified the association of non-adherence with the outcome. RESULTS:A total of 182 patients

SUBMITTER: Al-Sheyyab A 

PROVIDER: S-EPMC6796330 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature