Global differences in the prevalence of the CpG island methylator phenotype of colorectal cancer.

ABSTRACT: Background:CpG Island Methylator Phenotype (CIMP) is an epigenetic phenotype in CRC characterized by hypermethylation of CpG islands in promoter regions of tumor suppressor genes, leading to their transcriptional silencing and loss of function. While the prevalence of CRC differs across geographical regions, no studies have compared prevalence of CIMP-High phenotype across regions. The purpose of this project was to compare the prevalence of CIMP across geographical regions after adjusting for variations in methodologies to measure CIMP in a meta-analysis.

Methods:We searched PubMed, Medline, and Embase for articles focusing on CIMP published from 2000 to 2018. Two reviewers independently identified 111 articles to be included in final meta-analysis. We classified meth

SUBMITTER: Advani SM 

PROVIDER: S-EPMC6796359 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature