DNA methylation exploration for ARDS: a multi-omics and multi-microarray interrelated analysis.

ABSTRACT:

Background

Despite advances in clinical management, there are currently no novel therapeutic targets for acute respiratory distress syndrome (ARDS). DNA methylation, as a reversible process involved in the development and progression of many diseases, would be used as potential therapeutic targets to improve the treatment strategies of ARDS. However, the meaningful DNA methylation sites associated with ARDS still remain largely unknown. We sought to determine the difference in DNA methylation between ARDS patients and healthy participants, and simultaneously, the feasible DNA methylation markers for potential therapeutic targets were also explored.

Methods

Microarray data of human blood samples for ARDS and healthy participants up to June 2019 was searched in GEO database. T

SUBMITTER: Zhang S 

PROVIDER: S-EPMC6796364 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature