NANOG helps cancer cells escape NK cell attack by downregulating ICAM1 during tumorigenesis.

ABSTRACT: BACKGROUND:At the beginning of tumorigenesis, newly born cancer cells must successfully avoid attack by the immune system. Although most abnormal cells are efficiently identified and destroyed by the immune system, particularly by NK cells, the molecular mechanisms by which newly born cancer cells evade NK cell surveillance are not fully understood. METHODS:NK cell resistance of highly tumorigenic population of human prostate cancer (PCa) cells were confirmed by xenograft in SCID mice with or without NK cell neutralization. The mechanisms by which the tumorigenic PCa cells evaded NK cell attack were investigated by RNAseq, ChIPseq, generation of several transformants and xenograft in SCID mice. RESULTS:Here, we show that PCa cells have a strengthened ability to escape NK cell attack due to

SUBMITTER: Saga K 

PROVIDER: S-EPMC6796413 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature