The caudate nucleus undergoes dramatic and unique transcriptional changes in human prodromal Huntington's disease brain.

ABSTRACT:

Background

The mechanisms underlying neurodegeneration in the striatum of Huntingon's Disease (HD) brain are currently unknown. While the striatum is massively degenerated in symptomatic individuals, which makes cellular characterization difficult, it is largely intact in asymptomatic HD gene positive (HD+) individuals. Unfortunately, as striatal tissue samples from HD+ individuals are exceedingly rare, recent focus has been on the Brodmann Area 9 (BA9), a relatively unaffected region, as a surrogate tissue. In this study, we analyze gene expression in caudate nucleus (CAU) from two HD+ individuals and compare the results with healthy and symptomatic HD brains.

Methods

High-throughput mRNA sequencing (mRNA-Seq) datasets were generated from post-mortem CAU of 2 asymptomatic H

SUBMITTER: Agus F 

PROVIDER: S-EPMC6796419 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature