Association of circular RNAs and environmental risk factors with coronary heart disease.

ABSTRACT: BACKGROUND:Coronary heart disease (CHD) is a complex disease caused by multi-factors and a major threat to human health. Circular RNAs (circRNAs) have critical roles in various biological processes and diseases. This study explores the independent role of circRNAs and their interaction with environmental factors in CHD. METHODS:A case-control study was conducted from March 2015 to September 2017 in Fuzhou, China. A total of 585 CHD patients and 585 gender- and age-matched healthy controls were enrolled. Questionnaire survey, health examination and molecular biology laboratory testing were conducted. Microarray technology and quantitative real-time polymerase chain reaction (PCR) were used to profile the expression levels of circRNAs. The area under the curve (AUC) of the receiver operating

SUBMITTER: Sun Y 

PROVIDER: S-EPMC6796436 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature