Capture at the single cell level of metabolic modules distinguishing aggressive and indolent glioblastoma cells.

ABSTRACT: Glioblastoma cell ability to adapt their functioning to microenvironment changes is a source of the extensive intra-tumor heterogeneity characteristic of this devastating malignant brain tumor. A systemic view of the metabolic pathways underlying glioblastoma cell functioning states is lacking. We analyzed public single cell RNA-sequencing data from glioblastoma surgical resections, which offer the closest available view of tumor cell heterogeneity as encountered at the time of patients' diagnosis. Unsupervised analyses revealed that information dispersed throughout the cell transcript repertoires encoded the identity of each tumor and masked information related to cell functioning states. Data reduction based on an experimentally-defined signature of transcription factors overcame this hu

SUBMITTER: Saurty-Seerunghen MS 

PROVIDER: S-EPMC6796454 | biostudies-literature | 2019 Oct

REPOSITORIES: biostudies-literature