Biodistribution, shedding, and transmissibility of the oncolytic virus talimogene laherparepvec in patients with melanoma.

ABSTRACT:

Background

Talimogene laherparepvec (T-VEC) is an intralesionally delivered, modified herpes simplex virus type-1 oncolytic immunotherapy. The biodistribution, shedding, and potential transmission of T-VEC was systematically evaluated during and after completion of therapy in adults with advanced melanoma.

Methods

In this phase 2, single-arm, open-label study, T-VEC was administered into injectable lesions initially at 10⁶ plaque-forming units (PFU)/mL, 10⁸ PFU/mL 21 days later, and 10⁸ PFU/mL every 14 (±3) days thereafter. Injected lesions were covered with occlusive dressings for ≥1 week. Blood, urine, and swabs from exterior of occlusive dressings, surface of injected lesions, oral mucosa, anogenital area, and suspected herpetic lesions we

SUBMITTER: Andtbacka RHI 

PROVIDER: S-EPMC6796514 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature