Distinct gut metagenomics and metaproteomics signatures in prediabetics and treatment-naive type 2 diabetics.

ABSTRACT:

Background

The gut microbiota plays important roles in modulating host metabolism. Previous studies have demonstrated differences in the gut microbiome of T2D and prediabetic individuals compared to healthy individuals, with distinct disease-related microbial profiles being reported in groups of different age and ethnicity. However, confounding factors such as anti-diabetic medication hamper identification of the gut microbial changes in disease development.

Method

We used a combination of in-depth metagenomics and metaproteomics analyses of faecal samples from treatment-naïve type 2 diabetic (TN-T2D, n = 77), pre-diabetic (Pre-DM, n = 80), and normal glucose tolerant (NGT, n = 97) individuals to investigate compositional and functional changes of the gut microbiota and the

SUBMITTER: Zhong H 

PROVIDER: S-EPMC6796533 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature