Semantic deficits in ALS related to right lingual/fusiform gyrus network involvement.

ABSTRACT: BACKGROUND:The clinicopathological continuity between amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD) is well known. Although ALS demonstrates language symptoms similar to FTLD, including semantic dementia, word reading impairments in ALS have not been well studied. "Jukujikun" are Kanji-written words with irregular pronunciation comparable to "exception words" and useful for detecting semantic deficits in Japan. We conducted a cross-sectional study to investigate Jukujikun reading impairments and related network changes in ALS. METHODS:We enrolled 71 ALS patients and 69 healthy controls (HCs). Age-, sex-, and education matched HCs were recruited from another cohort study concurrently with patient registration. We examined neuropsychological factors includi

SUBMITTER: Ogura A 

PROVIDER: S-EPMC6796569 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature