Genotypic characterisation of monepantel resistance in historical and newly derived field strains of Teladorsagia circumcincta.

ABSTRACT: Recent reports of monepantel (MPTL) resistance in UK field isolates of Teladorsagia circumcincta has highlighted the need for a better understanding of the mechanism of MPTL-resistance in order to preserve its anthelmintic efficacy in this economically important species. Nine discrete populations of T. circumcincta were genotypically characterised; three MPTL-susceptible isolates, three experimentally selected MPTL-resistant strains and three field derived populations. Full-length Tci-mptl-1 gene sequences were generated and comparisons between the MPTL-susceptible isolates, MPTL-resistant strains and one field isolate, showed that different putative MPTL-resistance conferring mutations were present in different resistant isolates. Truncated forms of the Tci-mptl-1 gene were also observed.

SUBMITTER: Turnbull F 

PROVIDER: S-EPMC6796645 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature