Clinical characteristics and molecular epidemiology of children with meningitis in Tehran, Iran: a prospective study.

ABSTRACT: The molecular epidemiology of meningitis in children is unclear in Iran, and data are scarce. We aimed to characterize its clinical and paraclinical features as well as to determine the distribution of genotype/capsular types of common bacterial meningitis agents in children in Iran. All children suspected to have meningitis aged 4 days to 15 years were enrolled onto a prospective cross-sectional study from January 2015 to September 2017. Diagnostic values of clinical features, cerebrospinal fluid and serum parameters were evaluated independently and in combination with each other by multivariate logistic regression to develop a diagnostic rule. Genotype/capsular types of all the isolates were determined by targeting serotype-specific genes with uniplex or multiplex PCR. Among 119 patients

SUBMITTER: Pormohammad A 

PROVIDER: S-EPMC6796727 | biostudies-literature | 2019 Nov

REPOSITORIES: biostudies-literature