MiR-885-5p Negatively Regulates Warburg Effect by Silencing Hexokinase 2 in Liver Cancer.

ABSTRACT: Growing tumor cells possess a distinct metabolic phenomenon that allows them to preferentially utilize glucose through aerobic glycolysis, which is referred to as the "Warburg effect." Accumulating evidence suggests that microRNAs (miRNAs) could regulate such metabolic reprogramming. Our microarray analysis and quantitative real-time PCR validation revealed that miR-885-5p was strongly downregulated in hepatocellular carcinoma (HCC) tissues and cell lines. To investigate miR-885-5p's biological functions in HCC progression, malignant phenotypes were analyzed in different types of hypoxic model and indicated that overexpression of miR-885-5p significantly inhibited HCC cell proliferation and migration and induced apoptosis in vitro and tumor growth in vivo. Subsequent investigations of whet

SUBMITTER: Xu F 

PROVIDER: S-EPMC6796743 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature