Asthma and allergic rhinitis risk depends on house dust mite specific IgE levels in PARIS birth cohort children.

ABSTRACT:

Background

The natural history of allergic sensitization in childhood, and its impact on allergic disease development, needs to be clarified. This study aims to identify allergic sensitization and morbidity patterns during the first 8 years of life.

Methods

The study was conducted in the on-going population-based prospective Pollution and Asthma Risk: an Infant Study (PARIS) birth cohort. Sensitization profiles were identified by k-means clustering based upon allergen-specific IgE levels measured at 18 months and 8/9 years. Allergic morbidity profiles were identified by latent class analysis based on symptoms, symptom severity, treatments, and lifetime doctor-diagnoses of asthma, allergic rhinitis, and atopic dermatitis and on lower respiratory infections before 2 years.

SUBMITTER: Gabet S 

PROVIDER: S-EPMC6796773 | biostudies-literature | 2019 Sep

REPOSITORIES: biostudies-literature