Differential Effects of Oral Boluses of Vitamin D2 vs Vitamin D3 on Vitamin D Metabolism: A Randomized Controlled Trial.

ABSTRACT:

Context

Vitamin D2 and vitamin D3 have been hypothesized to exert differential effects on vitamin D metabolism.

Objective

To compare the influence of administering vitamin D2 vs vitamin D3 on metabolism of vitamin D3.

Methods

We measured baseline and 4-month serum concentrations of vitamin D3, 25-hydroxyvitamin D3 [25(OH)D3], 25-hydroxyvitamin D2, 24R,25-dihydroxyvitamin D3 [24R,25(OH)2D3], 1α,25-dihydroxyvitamin D3 [1α,25(OH)2D3], and 4β,25-dihydroxyvitamin D3 [4β,25(OH)2D3] in 52 adults randomized to receive a total of four oral bolus doses of 2.5 mg vitamin D2 (n = 28) or vitamin D3 (n = 24) over four months. Metabolite-to-parent compound ratios were calculated to estimate hydroxylase activity. Pairwise before vs after comparisons were made to evaluate effects of v

SUBMITTER: Martineau AR 

PROVIDER: S-EPMC6797055 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature